![]() Ĭorrelations of perfusion values with dominant hand finger tapping speed. Abbreviations: PC, parietal cortex SFG, superior frontal gyrus MTG, middle temporal gyrus MOG, middle occipital gyrus CN, cerebellar nuclei. Stuttering severity scale I incorporates information from stuttering persons about the severity of their symptoms as well as their general knowledge of stuttering Scale V is a total severity score, the sum of scales I–IV. Perfusion values in Broca's area correlated inversely with the severity of stuttering. ![]() Right Panel: Voxels in blue represent inverse correlations, and voxels in red represent positive correlations, between rCBF Z‐score perfusion values and stuttering severity scores, displayed at a threshold of P < 0.05 after correction for multiple comparisons. The vertically aligned z‐values at the left side of the figure represent slice level (in millimeters) in the Montreal Neurological Institute coordinate system. The second and third columns show the color‐coded maps of P‐value significance levels comparing individual‐level rCBF Z‐score perfusion values against a value of zero in a general linear model applied within the stuttering and control groups separately, thresholded at Z = 1.65, corresponding to P = 0.05 after correction for multiple comparisons. Perfusion values at rest in the stuttering group were lower bilaterally in Broca's area and the superior frontal gyrus, and higher in cerebellar nuclei and the parietal cortex, compared with fluent controls. Voxels in blue indicate reduced perfusion values in the stuttering group, and voxels in red indicate increased perfusion values, relative to controls. Left Panel: The first column represents the statistically significant differences in rCBF Z‐score perfusion values between the stuttering group and the fluent controls while covarying for age and sex of the participants, displayed at a threshold of P < 0.05 after correction for multiple comparisons. The right sides of the images correspond to the right side of the brain. Group differences and severity correlations. © 2017 Wiley Periodicals, Inc.īroca developmental stuttering perfusion pulsed arterial spin labeling stuttering. Moreover, a greater abnormality in rCBF in the posterior language loop is associated with more severe symptoms, suggesting that a common pathophysiology throughout the language loop likely contributes to stuttering severity. More severe stuttering is associated with even greater reductions in rCBF to Broca's region, additive to the underlying putative trait reduction in rCBF relative to control values. RCBF is reduced in Broca's region in persons who stutter. Findings were unchanged in child-only analyses and when excluding participants with comorbid illnesses or those taking medication. We also found increased rCBF in cerebellar nuclei and parietal cortex in the stuttering group compared with healthy controls. rCBF values in Broca's area bilaterally correlated inversely with the severity of stuttering and extended posteriorly into other portions of the language loop. We detected lower regional Cerebral Blood Flow (rCBF) at rest in the stuttering group compared with healthy controls in Broca's area bilaterally and the superior frontal gyrus. While covarying for age, sex, and IQ, we compared perfusion values voxel-wise across diagnostic groups and assessed correlations of perfusion with stuttering severity within the stuttering group and with measures of motor speed in both groups. We acquired pulsed arterial spin labeling magnetic resonance imaging data in 26 participants with stuttering and 36 healthy, fluent controls. To study resting cerebral blood flow in children and adults with developmental stuttering.
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